Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | GLA | P06280 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31636725 | 0.91 | KDM4E (0.56) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL3518114 | 0.91 | KDM4E (0.56) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL6224089 | 0.91 | KDM4E (0.56) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL6779214 | 0.88 | KDM4E (0.53) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL6779108 | 0.77 | ADORA2A (0.50) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL2725328 | 0.77 | MDM4 (0.45) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL6252164 | 0.75 | KDM4E (0.60) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL5794239 | 0.75 | KDM4E (0.60) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL6221455 | 0.74 | MAP4K4 (0.50) | KDM4EALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL31636670 | 0.74 | KDM4E (0.44) | KDM4EALDH1A1GAAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800650-B2 | FOR THERAPY AND PROPHYLAXIS OF DIABETES, PARTICULARLY NON-INSULIN DEPENDENT DIABETES MELLITUS AND IMPAIRED GLUCOSE TOLERANCE. | HOFFMANN-LA ROCHE INC. | 2004-10-05 | — | — | US | disclosed |