Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20143871 | 0.84 | PDPK1 (0.46) | SRCPDPK1ENPP1KDM4EALDH1A1 | |
| SCHEMBL17137310 | 0.82 | SRC (0.53) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL2747384 | 0.82 | SRC (0.46) | SRCPDPK1ENPP1KDM4EALDH1A1 | |
| SCHEMBL256577 | 0.82 | PDPK1 (0.47) | SRCPDPK1ENPP1KDM4EALDH1A1 | |
| SCHEMBL31716209 | 0.82 | SRC (0.46) | SRCPDPK1ENPP1KDM4EALDH1A1 | |
| SCHEMBL5706797 | 0.82 | EGFR (0.52) | SRCPDPK1ENPP1KDM4EALDH1A1 | |
| SCHEMBL6781301 | 0.82 | SRC (0.47) | SRCPDPK1ENPP1KDM4EALDH1A1 | |
| SCHEMBL2748840 | 0.82 | EGFR (0.48) | SRCPDPK1ENPP1KDM4EALDH1A1 | |
| SCHEMBL5706973 | 0.82 | SRC (0.47) | SRCPDPK1ENPP1KDM4EALDH1A1 | |
| SCHEMBL30288418 | 0.82 | EGFR (0.48) | SRCPDPK1ENPP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6809106-B1 | ANTIPROLIFERATION AGENTS; SUCH AS 4-(2-METHOXYPHENOXY)-ANILINO-3-CHLORO-6,7-DIMETHOXYQUINOLINE | ASTRAZENECA AB (SE) | 2004-10-26 | — | — | US | disclosed |
| EP-1178966-B1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1178966-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | AstraZeneca AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000068200-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2000-11-16 | — | — | WO | disclosed |