Semotiadil

Semotiadil

SCHEMBL678676

COc1ccc(OCCCN(C)CCOc2ccc3c(c2)OCO3)c(C2Sc3ccccc3N(C)C2=O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.68
EDNRA P25101 2/20 0.37
CACNA1S Q13698 1/20 0.36
DRD2 P14416 1/20 0.36
DRD3 P35462 1/20 0.36
MAOB P27338 2/20 0.36
MAPK1 P28482 2/20 0.36
MAPT P10636 3/20 0.36
TDP1 Q9NUW8 2/20 0.36
MAOA P21397 1/20 0.36
MEN1 O00255 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
TSHR P16473 1/20 0.35
CYP2C19 P33261 1/20 0.35
KMT2A Q03164 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Levosemotiadil SCHEMBL678293 1.00 CYP3A4 (0.68) CYP3A4EDNRACACNA1SDRD2DRD3
Semotiadil SCHEMBL80715 1.00 CYP3A4 (0.68) CYP3A4EDNRACACNA1SDRD2DRD3
Semotiadil SCHEMBL29396077 1.00 CYP3A4 (0.68) CYP3A4EDNRACACNA1SDRD2DRD3
SCHEMBL7376974 0.98 CYP3A4 (0.65) CYP3A4EDNRACACNA1SDRD2DRD3
SCHEMBL10676730 0.98 CYP3A4 (0.65) CYP3A4EDNRACACNA1SDRD2DRD3
Oxalic Acid SCHEMBL9748438 0.96 CYP3A4 (0.66) CYP3A4EDNRADRD2DRD3MAPK1
Semotiadil SCHEMBL7382921 0.94 CYP3A4 (0.64) CYP3A4EDNRADRD2DRD3MEN1
Levosemotiadil SCHEMBL30873510 0.94 CYP3A4 (0.64) CYP3A4EDNRADRD2DRD3MEN1
Semotiadil SCHEMBL7299290 0.94 CYP3A4 (0.64) CYP3A4EDNRADRD2DRD3MEN1
Semotiadil SCHEMBL7299286 0.94 CYP3A4 (0.64) CYP3A4EDNRADRD2DRD3MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104203985-A Cyclodextrin-based polymers for therapeutic delivery CERULEAN PHARMA INC 2014-12-10 CN claimed
CN-1315945-A Nitrate salts of antihypertensive drugs NICOX SA (FR) 2001-10-03 CN claimed
EP-0429676-B1 DRUG FOR IMPROVING BRAIN FUNCTION SANTEN PHARMACEUTICAL CO LTD (JP) 1996-09-18 EP claimed
US-5182276-A NOOTROPIC AGENT SANTEN PHARMACEUTICAL CO., LTD. (JP) 1993-01-26 US claimed
EP-0237573-B1 NOVEL BENZOTHIAZINE DERIVATIVES SANTEN PHARMACEUTICAL CO., LTD. (JP) 1992-01-15 EP claimed
EP-0429676-A1 DRUG FOR IMPROVING BRAIN FUNCTION SANTEN PHARMACEUTICAL CO., LTD (JP) 1991-06-05 EP claimed
US-4786635-A THERAPEUTIC AGENTS FOR CIRCULATORY DISEASES SANTEN PHARMACEUTICAL CO., LTD. (JP) 1988-11-22 US claimed
JP-9012576-A None JP disclosed
JP-8319237-A None JP disclosed
JP-3227981-A None JP disclosed
JP-3227929-A None JP disclosed
CN-105399751-A BUPRENORPHINE ANALOGS PURDUE PHARMA LP 2016-03-16 CN disclosed
CN-103380119-B As the amino butyric acid derivative be substituted of enkephalinase inhibitor THERAVANCE BIOPHARMA R&D IP, LLC (US) 2016-02-17 CN disclosed
JP-H0912576-A PRODUCTION OF BENZOTHIAZINE DERIVATIVE SANTEN PHARMACEUT CO LTD 1997-01-14 JP disclosed
JP-H08319237-A THERAPEUTIC AGENT FOR NETTED CHOROIDEA DISEASE SANTEN PHARMACEUT CO LTD 1996-12-03 JP disclosed
EP-0237573-B1 NOVEL BENZOTHIAZINE DERIVATIVES SANTEN PHARMACEUTICAL CO., LTD. (JP) 1992-01-15 EP disclosed
JP-H03227929-A DIURETICS SANTEN PHARMACEUT CO LTD 1991-10-08 JP disclosed
JP-H03227981-A CARDIOVASCULAR DISEASE REMEDY SANTEN PHARMACEUT CO LTD 1991-10-08 JP disclosed
US-4786635-A THERAPEUTIC AGENTS FOR CIRCULATORY DISEASES SANTEN PHARMACEUTICAL CO., LTD. (JP) 1988-11-22 US disclosed
EP-0237573-A1 NOVEL BENZOTHIAZINE DERIVATIVES SANTEN PHARMACEUTICAL CO., LTD. (JP) 1987-09-23 EP disclosed