Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 4/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6787707 | 1.00 | SRD5A1 (0.35) | SRD5A1SRD5A2TTRMAPKAPK2CDC7 | |
| Lithium Ion SCHEMBL6789822 | 0.92 | MAPKAPK2 (0.30) | MAPKAPK2CDC7PLK4CHEK1IKBKB | |
| Lithium Ion SCHEMBL6789834 | 0.92 | MAPKAPK2 (0.30) | MAPKAPK2CDC7PLK4CHEK1IKBKB | |
| SCHEMBL6791727 | 0.91 | SRD5A1 (0.34) | SRD5A1SRD5A2MAPKAPK2CDC7PLK4 | |
| SCHEMBL6791723 | 0.91 | SRD5A1 (0.34) | SRD5A1SRD5A2MAPKAPK2CDC7PLK4 | |
| SCHEMBL6795194 | 0.90 | MAPKAPK2 (0.41) | MAPKAPK2CDC7PLK4CHEK1IKBKB | |
| SCHEMBL6795191 | 0.90 | MAPKAPK2 (0.41) | MAPKAPK2CDC7PLK4CHEK1IKBKB | |
| SCHEMBL6788275 | 0.88 | PARP1 (0.38) | PLK4DAPK3DYRK3JAK2PRKD3 | |
| SCHEMBL6788280 | 0.88 | PARP1 (0.38) | PLK4DAPK3DYRK3JAK2PRKD3 | |
| SCHEMBL6791923 | 0.88 | MAPKAPK2 (0.33) | MAPKAPK2CDC7PLK4CHEK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | SRD5A1 2679/4885SRD5A2 1901/4885TTR 4806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.