Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 12/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.38 |
| ▸ | AURKA | O14965 | 6/20 | 0.38 |
| ▸ | MTOR | P42345 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 3/20 | 0.35 |
| ▸ | GPR39 | O43194 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.34 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660771 | 0.94 | MAPKAPK2 (0.41) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| Hydrochloric Acid SCHEMBL4263089 | 0.86 | CDK2 (0.44) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| SCHEMBL6794525 | 0.85 | MAPKAPK2 (0.41) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| SCHEMBL6794954 | 0.81 | MAPKAPK2 (0.39) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| SCHEMBL1660747 | 0.79 | MAPKAPK2 (0.43) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| SCHEMBL4272021 | 0.79 | MAPKAPK2 (0.38) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| Trifluoroacetic Acid SCHEMBL4267121 | 0.79 | MAPKAPK2 (0.44) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| Hydrochloric Acid SCHEMBL1655155 | 0.78 | HDAC1 (0.42) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| SCHEMBL4267125 | 0.77 | MAPKAPK2 (0.39) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| Hydrochloric Acid SCHEMBL4269768 | 0.76 | MAPKAPK2 (0.39) | MAPKAPK2CDK2CCNA2CCNA1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | MAPKAPK2 2/4885CDK2 29/4885CCNA2 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.