⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1199564 | 0.66 | — | — | |
| SCHEMBL7536285 | 0.65 | — | — | |
| SCHEMBL27995066 | 0.62 | — | — | |
| SCHEMBL19788975 | 0.56 | — | — | |
| SCHEMBL13479138 | 0.56 | — | — | |
| SCHEMBL13040648 | 0.53 | — | — | |
| SCHEMBL4722335 | 0.51 | — | — | |
| SCHEMBL6454776 | 0.51 | — | — | |
| SCHEMBL5799711 | 0.50 | — | — | |
| SCHEMBL12973030 | 0.49 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-05 | — | — | US | disclosed |
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |
| US-20040171630-A1 | both receptor-type and non-receptor type tyrosine kinases; to treat angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, | KIM YUNTAE (US) | 2004-09-02 | — | — | US | disclosed |
| WO-2002102783-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2002-12-27 | — | — | WO | disclosed |