Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 10/20 | 0.64 |
| ▸ | CDK2 | P24941 | 10/20 | 0.64 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792462 | 0.80 | AURKA (0.51) | CCNA2CDK2CCNA1AURKAMAPK10 | |
| SCHEMBL6788636 | 0.79 | CCNA2 (1.00) | CCNA2CDK2CCNA1AURKA | |
| Hydrochloric Acid SCHEMBL6792455 | 0.79 | CCNA2 (0.74) | CCNA2CDK2CCNA1HSD17B10ALDH1A1 | |
| SCHEMBL5230280 | 0.78 | CCNA2 (0.57) | CCNA2CDK2CCNA1AURKAMAPK10 | |
| SCHEMBL6794908 | 0.77 | AURKA (0.54) | CCNA2CDK2CCNA1AURKAMAPK10 | |
| Hydrochloric Acid SCHEMBL6799180 | 0.77 | CCNA2 (0.67) | CCNA2CDK2CCNA1HSD17B10ALDH1A1 | |
| SCHEMBL5230731 | 0.76 | CCNA2 (0.73) | CCNA2CDK2CCNA1 | |
| SCHEMBL425910 | 0.75 | AURKA (0.49) | CCNA2CDK2CCNA1AURKAMAPK10 | |
| SCHEMBL6795341 | 0.75 | KMT2A (0.51) | AURKAMAPK10RIPK1HSD17B10ALDH1A1 | |
| SCHEMBL6788929 | 0.75 | MEN1 (0.54) | AURKAMAPK10RIPK1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | CCNA2 270/4885CDK2 29/4885CCNA1 527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.