Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MTR | Q99707 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793543 | 0.95 | DRD3 (0.51) | MTTPDRD3CHRM2ADRA2AADORA3 | |
| SCHEMBL6794172 | 0.93 | MTTP (0.51) | MTTPDRD3CHRM2ADRA2AADORA3 | |
| SCHEMBL6793242 | 0.93 | DRD3 (0.55) | MTTPDRD3CHRM2ADRA2AADORA3 | |
| SCHEMBL6793761 | 0.92 | DRD3 (0.52) | MTTPDRD3CHRM2ADRA2AADORA3 | |
| SCHEMBL6794442 | 0.90 | DRD3 (0.53) | MTTPDRD3CHRM2ADRA2AADORA3 | |
| SCHEMBL6794621 | 0.90 | MTTP (0.48) | MTTPDRD3CHRM2ADRA2AADORA3 | |
| SCHEMBL6787814 | 0.90 | MTTP (0.54) | MTTPDRD3CHRM2ADRA2AADORA3 | |
| SCHEMBL6792149 | 0.90 | MTTP (0.59) | MTTPDRD3CHRM2ADRA2AADORA3 | |
| SCHEMBL6792573 | 0.89 | MTTP (0.54) | MTTPDRD3CHRM2ADRA2AADORA3 | |
| SCHEMBL6789961 | 0.88 | MTTP (0.59) | MTTPDRD3CHRM2ADRA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818644-B1 | FLUORENE-9-CARBOXYLIC AMIDES; INHIBITORS OF MICROSOMAL TRIGLYSERIDE-TRANSFER PROTEIN (MTP); ANTILIPEMIC AGENTS; ATHEROSCLEROSIS, DIABETES, EATING DISORDERS, AND PANCREATITIS | BOEHRINGER INGELHEIM PHARM GMBH & CO, KG (DE) | 2004-11-16 | — | — | US | disclosed |