SCHEMBL6792208

SCHEMBL6792208

CC(C)(C)NC(=O)NO

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL133932 0.83 NPC1 (0.44)
SCHEMBL20381814 0.78 NPC1 (0.41)
SCHEMBL603670 0.75
SCHEMBL11804099 0.73
SCHEMBL21424545 0.73
SCHEMBL15279118 0.73
SCHEMBL603669 0.73
SCHEMBL21928888 0.73
SCHEMBL5117544 0.73
SCHEMBL24226219 0.71 NPC1 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200354367-A1 COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-11-12 US disclosed
US-20200316062-A1 COMBINATIONS COMPRISING HISTONE DEACETYLASE INHIBITORS KARUS THERAPEUTICS LIMITED (GB) 2020-10-08 US disclosed
US-20180170876-A1 NOVEL HISTONE DEACETYLASE INHIBITORS KARUS THERAPEUTICS LIMITED (GB) 2018-06-21 US disclosed
US-20180086750-A1 NOVEL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY KARUS THERAPEUTICS LIMITED (GB) 2018-03-29 US disclosed
US-9862685-B2 Histone deacetylase inhibitors KARUS THERAPEUTICS LIMITED (GB) 2018-01-09 US disclosed
US-20170313698-A1 POLYHETEROARL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY KARUS THERAPEUTICS LIMITED (GB) 2017-11-02 US disclosed
US-20170313698-A1 POLYHETEROARL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY KARUS THERAPEUTICS LIMITED (GB) 2017-11-02 US disclosed
US-20170313712-A1 DIHETEROARYL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY KARUS THERAPEUTICS LIMITED (GB) 2017-11-02 US disclosed
US-20170313712-A1 DIHETEROARYL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY KARUS THERAPEUTICS LIMITED (GB) 2017-11-02 US disclosed
US-9676765-B2 Histone deacetylase inhibitors and their use in therapy KARUS THERAPEUTICS LIMITED (GB) 2017-06-13 US disclosed
US-20160096804-A1 NOVEL HISTONE DEACETYLASE INHIBITORS KARUS THERAPEUTICS LIMITED (GB) 2016-04-07 US disclosed
US-20150361074-A1 NOVEL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY KARUS THERAPEUTICS LIMITED (GB) 2015-12-17 US disclosed
US-6713629-B2 PLANT FUNGICIDE NIPPON SODA CO., LTD. (JP) 2004-03-30 US disclosed