Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4192663 | 0.82 | HPGD (0.59) | TDP1HPGDKMT2AMEN1NPC1 | |
| SCHEMBL4204369 | 0.82 | HPGD (0.59) | TDP1HPGDKMT2AMEN1NPC1 | |
| SCHEMBL7151770 | 0.82 | HPGD (0.64) | TDP1HPGDKMT2AMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL4208519 | 0.81 | HPGD (0.58) | TDP1HPGDKMT2AMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL27601234 | 0.81 | HPGD (0.58) | TDP1HPGDKMT2AMEN1NPC1 | |
| SCHEMBL9501904 | 0.80 | HPGD (0.61) | TDP1HPGDKMT2AMEN1NPC1 | |
| SCHEMBL7692022 | 0.80 | HPGD (0.61) | TDP1HPGDKMT2AMEN1NPC1 | |
| SCHEMBL6792743 | 0.79 | HPGD (0.56) | TDP1HPGDKMT2AMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL4203336 | 0.79 | HPGD (0.56) | TDP1HPGDKMT2AMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL4198786 | 0.79 | HPGD (0.56) | TDP1HPGDKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720351-B2 | 1H-INDOLE-2-CARBOXYLIC ACID (2-(BENZYL(METHYL)AMINO) -2-OXO-1-PHENYLETHYL)AMIDES; TRIAMIDE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) AND APOLIPOPROTEIN B (APO B) INHIBITORS; OBESITY; ANTILIPEMIC AGENTS | PFIZER INC. | 2004-04-13 | — | — | US | claimed |