⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5714 | 0.73 | — | — | |
| SCHEMBL20261722 | 0.70 | — | — | |
| Bromide SCHEMBL6950868 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL29266554 | 0.70 | — | — | |
| Iodide SCHEMBL10841278 | 0.70 | — | — | |
| SCHEMBL1740820 | 0.67 | — | — | |
| SCHEMBL17956808 | 0.64 | — | — | |
| SCHEMBL7476994 | 0.64 | — | — | |
| SCHEMBL19269020 | 0.60 | CRBN (0.33) | — | |
| SCHEMBL8057756 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030166666-A1 | Diimino-piperazine derivatives for use as modulators of cell regulation | MERRILL ALFRED H (US) | 2003-09-04 | — | — | US | claimed |
| WO-2001037836-A1 | DIIMINO-PIPERAZINE DERIVATIVES FOR USE AS MODULATORS OF CELL REGULATION | EMORY UNIVERSITY (US) | 2001-05-31 | — | — | WO | claimed |
| US-6750211-B2 | PREFERRED DERIVATIVE IS A NATURALLY OCCURING 2,6-BIS-(OMEGA-AMINOBUTYL)-3,5-DIIMINOPIPERAZINE; INHIBITION OF SPHINGOLIPID METABOLISM BY SUPPRESSING THE ?BURST?; ANTI- CARCINOGENIC, -INFLAMMATORY AGENTS; HEART ATTACK; STROKE | EMORY UNIVERSITY | 2004-06-15 | — | — | US | disclosed |
| US-6750211-B2 | PREFERRED DERIVATIVE IS A NATURALLY OCCURING 2,6-BIS-(OMEGA-AMINOBUTYL)-3,5-DIIMINOPIPERAZINE; INHIBITION OF SPHINGOLIPID METABOLISM BY SUPPRESSING THE ?BURST?; ANTI- CARCINOGENIC, -INFLAMMATORY AGENTS; HEART ATTACK; STROKE | EMORY UNIVERSITY | 2004-06-15 | — | — | US | disclosed |
| US-20030166666-A1 | Diimino-piperazine derivatives for use as modulators of cell regulation | MERRILL ALFRED H (US) | 2003-09-04 | — | — | US | disclosed |
| US-20030166666-A1 | Diimino-piperazine derivatives for use as modulators of cell regulation | MERRILL ALFRED H (US) | 2003-09-04 | — | — | US | disclosed |
| US-20030166666-A1 | Diimino-piperazine derivatives for use as modulators of cell regulation | MERRILL ALFRED H (US) | 2003-09-04 | — | — | US | disclosed |
| US-6552025-B1 | As inhibitors of sphingolipid metabolism; for therapy | EMORY UNIVERSITY | 2003-04-22 | — | — | US | disclosed |
| US-6552025-B1 | As inhibitors of sphingolipid metabolism; for therapy | EMORY UNIVERSITY | 2003-04-22 | — | — | US | disclosed |
| US-6552025-B1 | As inhibitors of sphingolipid metabolism; for therapy | EMORY UNIVERSITY | 2003-04-22 | — | — | US | disclosed |
| WO-2001037836-A1 | DIIMINO-PIPERAZINE DERIVATIVES FOR USE AS MODULATORS OF CELL REGULATION | EMORY UNIVERSITY (US) | 2001-05-31 | — | — | WO | disclosed |
| WO-2001037836-A1 | DIIMINO-PIPERAZINE DERIVATIVES FOR USE AS MODULATORS OF CELL REGULATION | EMORY UNIVERSITY (US) | 2001-05-31 | — | — | WO | disclosed |