Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.33 |
| ▸ | PLK1 | P53350 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6792909 | 1.00 | MAPKAPK2 (0.37) | MAPKAPK2MAPTALDH1A1LMNAPOLB | |
| SCHEMBL4267617 | 0.93 | MAPKAPK2 (0.41) | MAPKAPK2MAPTALDH1A1LMNAPOLB | |
| SCHEMBL4267623 | 0.93 | MAPKAPK2 (0.41) | MAPKAPK2MAPTALDH1A1LMNAPOLB | |
| Trifluoroacetic Acid SCHEMBL6794251 | 0.92 | POLB (0.35) | MAPKAPK2MAPTALDH1A1POLBGAA | |
| Trifluoroacetic Acid SCHEMBL6794255 | 0.92 | POLB (0.35) | MAPKAPK2MAPTALDH1A1POLBGAA | |
| Trifluoroacetic Acid SCHEMBL4255917 | 0.91 | MAPKAPK2 (0.30) | MAPKAPK2CDK2PLK1AURKACSNK1A1 | |
| Trifluoroacetic Acid SCHEMBL4255911 | 0.91 | MAPKAPK2 (0.30) | MAPKAPK2CDK2PLK1AURKACSNK1A1 | |
| Trifluoroacetic Acid SCHEMBL4256994 | 0.91 | MAPKAPK2 (0.36) | MAPKAPK2CCNA2CDK2CCNA1PLK1 | |
| Trifluoroacetic Acid SCHEMBL4256992 | 0.91 | MAPKAPK2 (0.36) | MAPKAPK2CCNA2CDK2CCNA1PLK1 | |
| SCHEMBL4255914 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | MAPKAPK2 2/4885MAPT 3143/4885ALDH1A1 4449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.