Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 17/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 17/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6794484 | 0.90 | CDK2 (0.45) | CDK2CCNA2CCNA1PDPK1AURKA | |
| Hydrochloric Acid SCHEMBL6792147 | 0.81 | CCNA2 (0.78) | CDK2CCNA2CCNA1IKBKB | |
| Hydrochloric Acid SCHEMBL6794562 | 0.74 | CDK2 (0.39) | CDK2CCNA2CCNA1PDPK1AURKA | |
| SCHEMBL6792712 | 0.73 | CCNA2 (0.65) | CDK2CCNA2CCNA1IKBKB | |
| SCHEMBL9940449 | 0.72 | CDK2 (0.64) | CDK2CCNA2CCNA1PDPK1AURKA | |
| SCHEMBL5229256 | 0.72 | CCNA2 (0.78) | CDK2CCNA2CCNA1IKBKB | |
| Hydrochloric Acid SCHEMBL9940658 | 0.72 | CDK2 (0.63) | CDK2CCNA2CCNA1PDPK1AURKA | |
| SCHEMBL6665468 | 0.71 | CCNA2 (0.72) | CDK2CCNA2CCNA1AURKAIKBKB | |
| SCHEMBL5231954 | 0.70 | CCNA2 (1.00) | CDK2CCNA2CCNA1IKBKB | |
| SCHEMBL9940634 | 0.70 | CDK2 (0.63) | CDK2CCNA2CCNA1PDPK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | CDK2 29/4885CCNA2 270/4885CCNA1 527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.