Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793775 | 1.00 | PARP1 (0.39) | PARP1CDK2PLK4DAPK3DYRK3 | |
| SCHEMBL6788275 | 0.92 | PARP1 (0.38) | PARP1CDK2PLK4DAPK3DYRK3 | |
| SCHEMBL6788280 | 0.92 | PARP1 (0.38) | PARP1CDK2PLK4DAPK3DYRK3 | |
| SCHEMBL6791723 | 0.88 | SRD5A1 (0.34) | CDK2PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL6791727 | 0.88 | SRD5A1 (0.34) | CDK2PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL6797263 | 0.87 | MAPKAPK2 (0.32) | PARP1CDK2PLK4DAPK3DYRK3 | |
| Hydrochloric Acid SCHEMBL6792330 | 0.86 | MAPKAPK2 (0.32) | PARP1CDK2PLK4DAPK3DYRK3 | |
| Hydrochloric Acid SCHEMBL6792337 | 0.86 | MAPKAPK2 (0.32) | PARP1CDK2PLK4DAPK3DYRK3 | |
| SCHEMBL4267623 | 0.84 | MAPKAPK2 (0.41) | GSK3BL3MBTL1LMNAALDH1A1GAA | |
| SCHEMBL6792648 | 0.83 | CSNK1A1 (0.36) | PARP1CDK2PLK4DAPK3DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | PARP1 2423/4885CDK2 29/4885PLK4 419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.