Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.79 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.79 |
| ▸ | CLK1 | P49759 | 4/20 | 0.79 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.79 |
| ▸ | CLK2 | P49760 | 3/20 | 0.79 |
| ▸ | CLK3 | P49761 | 2/20 | 0.79 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.79 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.79 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.79 |
| ▸ | GSK3B | P49841 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 7/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2884580 | 1.00 | DYRK1A (0.79) | DYRK1ADYRK1BCLK1DYRK2CLK2 | |
| SCHEMBL2884578 | 1.00 | DYRK1A (0.79) | DYRK1ADYRK1BCLK1DYRK2CLK2 | |
| SCHEMBL8187615 | 0.90 | DYRK1A (0.72) | DYRK1ADYRK1BCLK1DYRK2CLK2 | |
| SCHEMBL8187617 | 0.90 | DYRK1A (0.72) | DYRK1ADYRK1BCLK1DYRK2CLK2 | |
| SCHEMBL8188586 | 0.88 | DYRK1A (1.00) | DYRK1ADYRK1BCLK1DYRK2CLK2 | |
| SCHEMBL16762283 | 0.88 | DYRK1A (1.00) | DYRK1ADYRK1BCLK1DYRK2CLK2 | |
| SCHEMBL16762270 | 0.88 | DYRK1A (1.00) | DYRK1ADYRK1BCLK1DYRK2CLK2 | |
| SCHEMBL8188589 | 0.88 | DYRK1A (1.00) | DYRK1ADYRK1BCLK1DYRK2CLK2 | |
| SCHEMBL13196839 | 0.88 | DYRK1A (1.00) | DYRK1ADYRK1BCLK1DYRK2CLK2 | |
| SCHEMBL16762284 | 0.88 | DYRK1A (1.00) | DYRK1ADYRK1BCLK1DYRK2CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846925-B2 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2010-12-07 | — | — | US | disclosed |
| US-7846925-B2 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2010-12-07 | — | — | US | disclosed |
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | LABORATOIRES SERONO S.A. (CH) | 2009-12-10 | — | — | US | disclosed |
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | LABORATOIRES SERONO S.A. (CH) | 2009-12-10 | — | — | US | disclosed |
| US-20040092561-A1 | Azolidinone-vinyl fused -benzene derivatives | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | ZAP70, BRCA1, ZYX | DYRK1A 3161/4885DYRK1B 2749/4885CLK1 4202/4885 |
| US-20040092561-A1 | Azolidinone-vinyl fused -benzene derivatives | BRCA1, ZAP70, ZYX | DYRK1A 3475/4885DYRK1B 3208/4885CLK1 4099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.