Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.71 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.53 |
| ▸ | GAK | O14976 | 3/20 | 0.51 |
| ▸ | FBP1 | P09467 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 4/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.49 |
| ▸ | BUB1 | O43683 | 2/20 | 0.49 |
| ▸ | STK10 | O94804 | 2/20 | 0.49 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.49 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.49 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6794863 | 0.89 | EGFR (0.74) | EGFRABCG2GAKFBP1ALDH1A1 | |
| SCHEMBL6794722 | 0.83 | EGFR (1.00) | EGFRFBP1ALDH1A1MAPTERBB2 | |
| SCHEMBL6794377 | 0.83 | EGFR (0.78) | EGFRABCG2GAKFBP1MAPT | |
| SCHEMBL6795102 | 0.83 | EGFR (1.00) | EGFRFBP1KDRERBB2SRC | |
| SCHEMBL7702775 | 0.80 | EGFR (0.76) | EGFRABCG2GAKFBP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7708472 | 0.79 | EGFR (0.77) | EGFRABCG2GAKFBP1ALDH1A1 | |
| SCHEMBL22367380 | 0.77 | EGFR (0.66) | EGFRABCG2GAKFBP1ALDH1A1 | |
| SCHEMBL17845926 | 0.75 | MAPK1 (0.65) | EGFRABCG2GAKFBP1MAPT | |
| SCHEMBL13285619 | 0.74 | EGFR (0.72) | EGFRABCG2GAKFBP1ALDH1A1 | |
| SCHEMBL6792872 | 0.71 | EGFR (0.76) | EGFRFBP1ALDH1A1MAPTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6835735-B2 | Anticancer, tyrosine kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-12-28 | — | — | US | disclosed |
| US-20030045537-A1 | 4-(Phenylamino)-[1,4]dioxano[2,3-g]quinazoline derivatives and process for preparing the same | KOREAN INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045537-A1 | 4-(Phenylamino)-[1,4]dioxano[2,3-g]quinazoline derivatives and process for preparing the same | EGFR, ERBB2, ERBB4 | EGFR 1/4885ABCG2 155/4885GAK 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.