Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 1.00 |
| ▸ | ACHE | P22303 | 4/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5889124 | 0.82 | KDR (0.69) | KDR | |
| SCHEMBL5889069 | 0.79 | KDR (1.00) | KDR | |
| SCHEMBL6180867 | 0.77 | KDR (0.68) | KDR | |
| SCHEMBL6178074 | 0.77 | KDR (1.00) | KDRCHEK1 | |
| SCHEMBL6179460 | 0.77 | KDR (0.67) | KDRCHEK1 | |
| SCHEMBL20804981 | 0.74 | PANK3 (0.61) | KDRACHE | |
| SCHEMBL6180656 | 0.73 | KDR (0.83) | KDRCHEK1 | |
| SCHEMBL5743045 | 0.73 | KDR (0.75) | KDR | |
| SCHEMBL5889092 | 0.72 | KDR (0.72) | KDR | |
| SCHEMBL6179215 | 0.72 | KDR (0.68) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063720-A1 | Tyrosine kinase inhibitors | MERCK & CO., INC. | 2004-04-01 | — | — | US | disclosed |
| US-20020137755-A1 | Tyrosine kinase inhibitors | BILODEAU MARK T (US) | 2002-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137755-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | KDR 5/4885ACHE 4813/4885CHEK1 499/4885 |
| US-20040063720-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | KDR 5/4885ACHE 4813/4885CHEK1 499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.