Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN12 | Q05209 | 1/20 | 0.55 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247449 | 0.89 | PTPN12 (0.51) | PTPN12PTPN22ALDH1A1MAPTMEN1 | |
| SCHEMBL6796892 | 0.87 | PTPN12 (0.50) | PTPN12PTPN22ALDH1A1MAPTMEN1 | |
| SCHEMBL5253984 | 0.87 | PTPN12 (0.50) | PTPN12PTPN22ALDH1A1MAPTMEN1 | |
| SCHEMBL5254121 | 0.86 | PTPN12 (0.49) | PTPN12PTPN22ALDH1A1MAPTMEN1 | |
| SCHEMBL6796700 | 0.86 | PTPN12 (0.49) | PTPN12PTPN22ALDH1A1MAPTMEN1 | |
| SCHEMBL5247483 | 0.86 | PTPN12 (0.49) | PTPN12PTPN22ALDH1A1MAPTMEN1 | |
| SCHEMBL6216645 | 0.85 | PDE5A (0.57) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL6796924 | 0.85 | PTPN12 (0.48) | PTPN12PTPN22ALDH1A1MAPTMEN1 | |
| SCHEMBL6213101 | 0.85 | MEN1 (0.47) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL5251584 | 0.85 | PTPN12 (0.49) | PTPN12PTPN22ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780867-B2 | THEY EXHIBIT SPECIFIC INHIBITION OF CGMP PHOSPHODIESTERASE (PDE V) | MERCK PATENT GMBH (DE) | 2004-08-24 | — | — | US | disclosed |
| US-20030187260-A1 | Thienopyrimidines | MERCK PATENT GMBH (DE) | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187260-A1 | Thienopyrimidines | TYMP, DPYD, IMPDH1 | PTPN12 1112/4885PTPN22 1078/4885ALDH1A1 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.