Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | UGT2B17 | O75795 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL702951 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAUGT2B17GAATDP1 | |
| SCHEMBL15286855 | 0.75 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAUGT2B17GAATDP1 | |
| SCHEMBL704984 | 0.75 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAUGT2B17GAATDP1 | |
| SCHEMBL705489 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAUGT2B17GAATDP1 | |
| SCHEMBL705490 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAUGT2B17GAATDP1 | |
| SCHEMBL16527051 | 0.71 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAUGT2B17ALDH1A1KDM4E | |
| SCHEMBL4869436 | 0.70 | TYMS (0.39) | SMN1; SMN2LMNAUGT2B17GAATDP1 | |
| SCHEMBL6783870 | 0.70 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAUGT2B17GAATDP1 | |
| SCHEMBL7647664 | 0.69 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAUGT2B17GAATDP1 | |
| SCHEMBL6783536 | 0.69 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAUGT2B17GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750243-B1 | COMPETITIVE INHIBITORS OF TRYPSIN-LIKE SERINE PROTEASES, ESPECIALLY THROMBIN; chemical synthesis; anticoagulants; treatment of thrombosis | AstraZeneća AB (SE) | 2004-06-15 | — | — | US | claimed |