Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.68 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307544 | 1.00 | GAA (0.71) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13668924 | 0.90 | HDAC3 (0.73) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1066988 | 0.89 | HDAC3 (0.81) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12426307 | 0.86 | GAA (0.82) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13149787 | 0.84 | GAA (0.73) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15672954 | 0.84 | GAA (0.73) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6245092 | 0.83 | GAA (1.00) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7776518 | 0.83 | GAA (0.83) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| Iodide SCHEMBL3141619 | 0.83 | GAA (0.71) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20221271 | 0.83 | GAA (0.71) | GAAHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828427-B1 | Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |
| US-6750344-B1 | MONOCYCLIC AMINE SCAFFOLD BEARING AT LEAST TWO SITES OF DIVERSITY, CYCLIZED TO FORM BICYCLIC AMINE SCAFFOLDS; 7-AMINO-PYRROLO(1,2-A)PYRAZIN-4-ONE COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-6316626-B1 | Amine compounds and combinatorial libraries comprising same | ISIS PHARMACEUTICALS, INC. | 2001-11-13 | — | — | US | disclosed |