Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.60 |
| ▸ | AURKA | O14965 | 3/20 | 0.60 |
| ▸ | PARP1 | P09874 | 15/20 | 0.57 |
| ▸ | DHODH | Q02127 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | ITK | Q08881 | 1/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6807295 | 0.97 | AURKB (0.63) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6810671 | 0.95 | AURKB (0.63) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6800793 | 0.93 | PARP1 (0.63) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6805128 | 0.93 | AURKB (0.66) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6801867 | 0.91 | AURKB (0.67) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6800047 | 0.89 | PARP1 (0.56) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6806228 | 0.89 | AURKB (0.58) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6806488 | 0.89 | PARP1 (0.61) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6588412 | 0.88 | AURKB (0.46) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6809857 | 0.88 | AURKB (0.70) | AURKBAURKAPARP1DHODHKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |