Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 9/20 | 0.47 |
| ▸ | DHODH | Q02127 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805060 | 0.99 | AURKB (0.53) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6811064 | 0.92 | AURKB (0.47) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6806577 | 0.92 | AURKB (0.47) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6810673 | 0.92 | AURKB (0.49) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6807525 | 0.92 | AURKB (0.47) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6810479 | 0.92 | AURKB (0.49) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6801165 | 0.91 | AURKB (0.47) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6810492 | 0.90 | AURKB (0.52) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6809921 | 0.89 | AURKB (0.54) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6805447 | 0.87 | AURKB (0.48) | AURKBPIM1PIM3MKNK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |