Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
| ▸ | PARP1 | P09874 | 15/20 | 0.64 |
| ▸ | DHODH | Q02127 | 3/20 | 0.58 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.55 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805911 | 0.91 | AURKA (0.74) | AURKAAURKBKDRPARP1DHODH | |
| SCHEMBL6806387 | 0.90 | AURKA (0.73) | AURKAAURKBKDRPARP1DHODH | |
| SCHEMBL6809970 | 0.90 | AURKA (0.73) | AURKAAURKBKDRPARP1DHODH | |
| SCHEMBL6805034 | 0.89 | AURKA (0.78) | AURKAAURKBKDRPARP1DHODH | |
| SCHEMBL6805718 | 0.89 | AURKA (0.72) | AURKAAURKBKDRPARP1DHODH | |
| SCHEMBL6806343 | 0.88 | AURKA (0.78) | AURKAAURKBKDRPARP1DHODH | |
| SCHEMBL6810125 | 0.86 | AURKA (0.74) | AURKAAURKBKDRPARP1DHODH | |
| SCHEMBL6810284 | 0.85 | AURKA (0.71) | AURKAAURKBKDRPARP1DHODH | |
| SCHEMBL6812389 | 0.85 | AURKA (0.67) | AURKAAURKBKDRPARP1DHODH | |
| SCHEMBL6805085 | 0.85 | AURKA (0.83) | AURKAAURKBKDRPARP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |