Histidine

Histidine

SCHEMBL6803056

CC(C)[C@H](N)C(N)=O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.38

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 4/20 0.38
CYP3A4 P08684 1/20 0.38
CYP1A2 P05177 1/20 0.38
GRIA1 P42261 6/20 0.36
GRIA3 P42263 6/20 0.36
GRIA4 P48058 6/20 0.36
GRIA2 P42262 5/20 0.36
ALPI P09923 1/20 0.34
PKM P14618 1/20 0.34
PTGS1 P23219 1/20 0.34
XIAP P98170 1/20 0.34
GRIK5 Q16478 3/20 0.33
GRIK1 P39086 2/20 0.33
GRIK2 Q13002 2/20 0.33
GRIK3 Q13003 2/20 0.33
GRIK4 Q16099 2/20 0.33
NOS3 P29474 2/20 0.33
NOS1 P29475 2/20 0.33
NOS2 P35228 2/20 0.33
KDM4E B2RXH2 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL6803051 1.00 SLC7A5 (0.38) SLC7A5CYP3A4CYP1A2GRIA1GRIA3
Histidine SCHEMBL1061772 0.92 SLC7A5 (0.43) SLC7A5CYP3A4CYP1A2GRIA1GRIA3
Histidine SCHEMBL1061774 0.92 SLC7A5 (0.43) SLC7A5CYP3A4CYP1A2GRIA1GRIA3
Histidine SCHEMBL1537307 0.92 SLC7A5 (0.43) SLC7A5CYP3A4CYP1A2GRIA1GRIA3
Histidine SCHEMBL27486516 0.90 SLC7A5 (0.42) SLC7A5CYP3A4CYP1A2GRIA1GRIA3
Histidine SCHEMBL27615468 0.90 SLC7A5 (0.41) SLC7A5CYP3A4CYP1A2GRIA1GRIA3
Histidine SCHEMBL3492735 0.89 SLC7A5 (0.41) SLC7A5CYP3A4CYP1A2GRIA1GRIA3
Histidine SCHEMBL2728163 0.89 SLC7A5 (0.41) SLC7A5CYP3A4CYP1A2GRIA1GRIA3
Histidine SCHEMBL6801012 0.88 SLC7A5 (0.36) SLC7A5CYP3A4CYP1A2GRIA1GRIA3
Histidine SCHEMBL6801013 0.88 SLC7A5 (0.36) SLC7A5CYP3A4CYP1A2GRIA1GRIA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1358485-A2 METHODS FOR IDENTIFYING COMPOUNDS FOR REGULATING MUSCLE MASS OR FUNCTION USING VASOACTIVE INTESTINAL PEPTIDE RECEPTORS THE PROCTER & GAMBLE COMPANY (US) 2003-11-05 EP claimed
WO-2002035240-A2 METHODS FOR IDENTIFYING COMPOUNDS FOR REGULATING MUSCLE MASS OR FUNCTION USING VASOACTIVE INTESTINAL PEPTIDE RECEPTORS THE PROCTER & GAMBLE COMPANY (US) 2002-05-02 WO claimed
US-20040176298-A1 Methods for identifying compounds for regulating muscle mass or function using vasoactive intestinal peptide receptors THE PROCTER & GAMBLE COMPANY (US) 2004-09-09 US disclosed
US-6750194-B1 ADMINISTERING TO THE SUBJECT A SAFE AND EFFECTIVE AMOUNT OF A VPAC RECEPTOR AGONIST SELECTED FROM THE GROUP CONSISTING OF RO 25-1553, AND PACAP-38 THE PROCTER & GAMBLE COMPANY 2004-06-15 US disclosed
EP-1358485-A2 METHODS FOR IDENTIFYING COMPOUNDS FOR REGULATING MUSCLE MASS OR FUNCTION USING VASOACTIVE INTESTINAL PEPTIDE RECEPTORS THE PROCTER & GAMBLE COMPANY (US) 2003-11-05 EP disclosed
WO-2002035240-A2 METHODS FOR IDENTIFYING COMPOUNDS FOR REGULATING MUSCLE MASS OR FUNCTION USING VASOACTIVE INTESTINAL PEPTIDE RECEPTORS THE PROCTER & GAMBLE COMPANY (US) 2002-05-02 WO disclosed