Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3322069 | 0.77 | EGFR (0.54) | EGFRSYKJAK2MAPK1L3MBTL1 | |
| SCHEMBL10138757 | 0.77 | GSK3B (0.56) | EGFRJAK2MAPK1L3MBTL1TDP1 | |
| SCHEMBL13202019 | 0.76 | KMT2A (0.53) | EGFRJAK2MAPK1L3MBTL1TDP1 | |
| SCHEMBL6802199 | 0.76 | EGFR (0.48) | EGFRABL1BCRSRCPRKCA | |
| SCHEMBL6801686 | 0.76 | GAA (0.46) | EGFRSYKJAK2MAPK1L3MBTL1 | |
| SCHEMBL2654269 | 0.75 | EGFR (0.46) | EGFRABL1PDGFRBBCRSRC | |
| SCHEMBL8592858 | 0.71 | ABL1 (0.67) | EGFRABL1PDGFRBBCRSRC | |
| SCHEMBL2655019 | 0.71 | EGFR (0.43) | EGFRABL1PDGFRBBCRSRC | |
| SCHEMBL7124011 | 0.70 | ABL1 (0.49) | EGFRABL1PDGFRBBCRSRC | |
| SCHEMBL2649704 | 0.70 | ABL1 (0.45) | EGFRABL1PDGFRBBCRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723735-B1 | TREATMENT OR PREVENTION OF ANXIETY | MERCK SHARP & DOHME LTD. | 2004-04-20 | — | — | US | disclosed |
| EP-1214319-B1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-11-26 | — | — | EP | disclosed |