Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6712463 | 0.93 | HTR2A (0.59) | HTR2AHTR2CMAPTRXFP1REN | |
| SCHEMBL6718449 | 0.93 | HTR2A (0.57) | HTR2AHTR2CNPC1HTTSMN1; SMN2 | |
| SCHEMBL6715495 | 0.83 | HTR2A (0.60) | HTR2AHTR2CMAPTNPC1SMN1; SMN2 | |
| SCHEMBL6714643 | 0.81 | HTR2A (0.60) | HTR2AHTR2CRENNPC1MEN1 | |
| SCHEMBL6715343 | 0.79 | HTR2A (0.69) | HTR2AHTR2CRENNPC1POLB | |
| SCHEMBL6712421 | 0.79 | HTR2A (0.60) | HTR2AHTR2CTP53MAPTNPC1 | |
| SCHEMBL6718713 | 0.79 | HTR2A (0.55) | HTR2AHTR2CRENNPC1MEN1 | |
| SCHEMBL6711345 | 0.79 | HTR2A (0.57) | HTR2AHTR2CTP53MAPTRXFP1 | |
| SCHEMBL6712411 | 0.78 | HTR2A (0.54) | HTR2AHTR2CTP53MAPTPOLB | |
| SCHEMBL6710856 | 0.78 | HTR2A (0.61) | HTR2AHTR2CMAPTNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6734301-B2 | 5-HT LIGANDS USED TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY | 2004-05-11 | — | — | US | claimed |