Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.56 |
| ▸ | HTR2C | P28335 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6713824 | 0.94 | HTR2A (0.54) | HTR2AHTR2CMAPTSMN1; SMN2KDM4E | |
| SCHEMBL6713671 | 0.87 | HTR2A (0.64) | HTR2AHTR2CSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6714033 | 0.82 | HTR2A (0.62) | HTR2AHTR2CMAPTSMN1; SMN2KDM4E | |
| SCHEMBL6713950 | 0.81 | HTR2A (0.60) | HTR2AHTR2CMAPTMEN1KMT2A | |
| SCHEMBL6715593 | 0.81 | HTR2A (0.60) | HTR2AHTR2CMAPTSMN1; SMN2MEN1 | |
| SCHEMBL6713947 | 0.80 | HTR2A (0.61) | HTR2AHTR2CMAPTMEN1KMT2A | |
| SCHEMBL6711473 | 0.79 | HTR2A (0.64) | HTR2AHTR2CPOLB | |
| SCHEMBL6718474 | 0.79 | HTR2A (0.58) | HTR2AHTR2CMAPTSMN1; SMN2RAB9A | |
| SCHEMBL6718705 | 0.79 | HTR2C (0.58) | HTR2AHTR2CMAPTKDM4EMEN1 | |
| SCHEMBL6712404 | 0.79 | HTR2C (0.60) | HTR2AHTR2CKDM4EKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6734301-B2 | 5-HT LIGANDS USED TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY | 2004-05-11 | — | — | US | claimed |