Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 6/20 | 0.74 |
| ▸ | PIM1 | P11309 | 3/20 | 0.74 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.74 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.74 |
| ▸ | KDR | P35968 | 2/20 | 0.74 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.74 |
| ▸ | GSK3A | P49840 | 2/20 | 0.74 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.74 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.74 |
| ▸ | SRC | P12931 | 1/20 | 0.74 |
| ▸ | FLT4 | P35916 | 1/20 | 0.74 |
| ▸ | CLK2 | P49760 | 1/20 | 0.74 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.74 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.74 |
| ▸ | AURKA | O14965 | 3/20 | 0.65 |
| ▸ | PARP1 | P09874 | 14/20 | 0.63 |
| ▸ | DHODH | Q02127 | 3/20 | 0.57 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806316 | 0.97 | AURKB (0.70) | AURKBPIM1PIM3MKNK2KDR | |
| SCHEMBL6810462 | 0.95 | AURKB (0.66) | AURKBPIM1PIM3MKNK2KDR | |
| SCHEMBL6800785 | 0.94 | AURKB (0.67) | AURKBPIM1PIM3MKNK2KDR | |
| SCHEMBL6805423 | 0.92 | AURKB (0.64) | AURKBPIM1PIM3MKNK2KDR | |
| SCHEMBL6806569 | 0.92 | AURKB (0.63) | AURKBPIM1PIM3MKNK2KDR | |
| SCHEMBL6803460 | 0.91 | AURKB (0.64) | AURKBPIM1PIM3MKNK2KDR | |
| SCHEMBL6810368 | 0.90 | AURKB (0.70) | AURKBPIM1PIM3MKNK2KDR | |
| SCHEMBL6801131 | 0.89 | AURKB (0.64) | AURKBPIM1PIM3MKNK2KDR | |
| SCHEMBL6805413 | 0.88 | AURKB (0.60) | AURKBPIM1PIM3MKNK2KDR | |
| SCHEMBL6806355 | 0.88 | AURKB (0.67) | AURKBPIM1PIM3MKNK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |