Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2763753 | 0.72 | TSHR (0.33) | TSHR | |
| SCHEMBL610211 | 0.67 | TSHR (0.47) | TSHR | |
| SCHEMBL8059804 | 0.65 | TSHR (0.32) | TSHR | |
| SCHEMBL6840931 | 0.65 | — | — | |
| SCHEMBL1060663 | 0.64 | TSHR (0.30) | TSHR | |
| SCHEMBL887785 | 0.64 | TSHR (0.30) | TSHR | |
| SCHEMBL10338559 | 0.63 | TSHR (0.41) | TSHR | |
| SCHEMBL114674 | 0.61 | — | — | |
| SCHEMBL23783512 | 0.61 | — | — | |
| SCHEMBL8595601 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180142236-A1 | SYNTHETIC SINGLE GUIDE RNA FOR CAS9-MEDIATED GENE EDITING | DHARMACON, INC. | 2018-05-24 | — | — | US | disclosed |
| EP-3294880-A1 | SYNTHETIC SINGLE GUIDE RNA FOR CAS9-MEDIATED GENE EDITING | Dharmacon, Inc. (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2016186745-A1 | SYNTHETIC SINGLE GUIDE RNA FOR CAS9-MEDIATED GENE EDITING | GE HEALTHCARE DHARMACON, INC. (US) | 2016-11-24 | — | — | WO | disclosed |
| US-6750357-B1 | STABLE FULLY SUBSTITUTED AMIDE LINKAGE AT THE 3-POSITION CARBOXYLATE; LABELED OLIGONUCLEOTIDE CONJUGATES BY SOLID PHASE SYNTHESIS | SYNGEN, INC. | 2004-06-15 | — | — | US | disclosed |
| US-6184379-B1 | FLUORESCENT DYES USED IN DIAGNOSIS | ROCHE DIAGNOSTICS GMBH (DE) | 2001-02-06 | — | — | US | disclosed |
| EP-0874857-A1 | SYNTHESIS OF POLYMERISABLE PHOSPHODIESTERS | BIOCOMPATIBLES LIMITED (GB) | 1998-11-04 | — | — | EP | disclosed |
| EP-0863908-A1 | OXIDATION OF PHOSPHORUS COMPOUNDS | BIOCOMPATIBLES LIMITED (GB) | 1998-09-16 | — | — | EP | disclosed |
| US-5639867-A | TTTr as protective group in nucleotide synthesis | CIBA GEIGY CORPORATION (US) | 1997-06-17 | — | — | US | disclosed |
| WO-1997014703-A1 | SYNTHESIS OF POLYMERISABLE PHOSPHODIESTERS | BIOCOMPATIBLES LIMITED (GB) | 1997-04-24 | — | — | WO | disclosed |
| WO-1997014702-A1 | OXIDATION OF PHOSPHORUS COMPOUNDS | BIOCOMPATIBLES LIMITED (GB) | 1997-04-24 | — | — | WO | disclosed |
| EP-0315499-B1 | NUCLEOSIDE DERIVATIVES, PARTICULARLY OF 2'-DEOXYCYTIDINE, AND THEIR USE IN THE SYNTHESIS OF OLIGONUCLEOTIDES | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1993-04-07 | — | — | EP | disclosed |
| EP-0315499-A1 | Nucleoside derivatives, particularly of 2'-deoxycytidine, and their use in the synthesis of oligonucleotides | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1989-05-10 | — | — | EP | disclosed |