Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 6/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805265 | 1.00 | PIM1 (0.50) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6805715 | 0.99 | PIM1 (0.51) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6811032 | 0.95 | PIM1 (0.45) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6805548 | 0.95 | PIM1 (0.45) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6807423 | 0.94 | PIM1 (0.45) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6806668 | 0.92 | PIM1 (0.45) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6805712 | 0.92 | PIM1 (0.47) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6801493 | 0.89 | AURKB (0.42) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6806656 | 0.87 | CARM1 (0.42) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6805777 | 0.86 | PRKD3 (0.53) | PIM1PIM3AURKBMKNK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |