Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | PARP1 | P09874 | 10/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805815 | 0.97 | AURKB (0.43) | AURKBAURKAPARP1TBK1DHODH | |
| SCHEMBL6806241 | 0.95 | AURKB (0.43) | AURKBAURKAPARP1TBK1DHODH | |
| SCHEMBL6800061 | 0.92 | PARP1 (0.41) | AURKBAURKAPARP1TBK1DHODH | |
| SCHEMBL6805150 | 0.92 | AURKB (0.49) | AURKBAURKAPARP1TBK1DHODH | |
| SCHEMBL6806498 | 0.89 | AURKB (0.46) | AURKBAURKAPARP1TBK1DHODH | |
| SCHEMBL6810685 | 0.89 | AURKB (0.47) | AURKBAURKAPARP1TBK1DHODH | |
| SCHEMBL6806075 | 0.89 | AURKB (0.51) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6806881 | 0.87 | AURKB (0.61) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6806368 | 0.86 | AURKB (0.49) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6807309 | 0.86 | AURKB (0.47) | AURKBAURKAPARP1TBK1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |