Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | RAB9A | P51151 | 3/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10826050 | 0.93 | SMN1; SMN2 (0.86) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL8843713 | 0.86 | SMN1; SMN2 (0.90) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL6811211 | 0.86 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL8356708 | 0.85 | NPC1 (0.64) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL6812864 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL21436905 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL6812174 | 0.82 | SMN1; SMN2 (0.73) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL6811499 | 0.82 | SMN1; SMN2 (0.73) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL27396917 | 0.81 | SMN1; SMN2 (0.71) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL31528139 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9ANPC1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828513-B1 | COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS | PFIZER (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-0777652-B1 | NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES | PFIZER (US) | 2003-06-25 | — | — | EP | disclosed |
| US-6258827-B1 | HYDROXYAROMATIC HETEROCYCLIC ALKANOLS AND LEVODOPA | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| US-6046213-A | Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives | PFIZER INC. (US) | 2000-04-04 | — | — | US | disclosed |
| CN-1159325-A | Co-therapy for Parkinson's syndrome | PFIZER (US) | 1997-09-17 | — | — | CN | disclosed |