Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.74 |
| ▸ | CCND1 | P24385 | 14/20 | 0.74 |
| ▸ | CCND2 | P30279 | 12/20 | 0.74 |
| ▸ | CCND3 | P30281 | 12/20 | 0.74 |
| ▸ | WEE1 | P30291 | 1/20 | 0.73 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.71 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.71 |
| ▸ | PAK4 | O96013 | 2/20 | 0.71 |
| ▸ | PAK3 | O75914 | 2/20 | 0.62 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.57 |
| ▸ | CDK2 | P24941 | 5/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.57 |
| ▸ | CDK1 | P06493 | 3/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659714 | 0.90 | CDK4 (0.72) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL1681080 | 0.89 | CDK4 (0.71) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL10192790 | 0.87 | WEE1 (0.77) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL5265052 | 0.85 | CDK4 (1.00) | CDK4CCND1CCND2CCND3PAK1 | |
| SCHEMBL13553998 | 0.85 | WEE1 (0.72) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL15785467 | 0.85 | WEE1 (0.69) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL15785468 | 0.85 | WEE1 (0.69) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL15035991 | 0.85 | PAK1 (0.69) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL15036160 | 0.85 | PAK1 (0.67) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL13553528 | 0.85 | PAK1 (0.69) | CDK4CCND1CCND2CCND3WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224958-A1 | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease | BOOTH RICHARD JOHN (US) | 2004-11-11 | — | — | US | disclosed |
| CN-1433417-A | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease | WARNER LAMBERT CO (US) | 2003-07-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224958-A1 | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease | CDK4, CDKL1, CCNT1 | CDK4 1/4885CCND1 23/4885CCND2 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.