Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | FDPS | P14324 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTPRA | P18433 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1166481 | 0.98 | — | — | |
| SCHEMBL1043027 | 0.81 | HRH1 (0.54) | HRH1SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL21985094 | 0.79 | HRH1 (0.52) | HRH1SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL21122917 | 0.77 | HRH1 (0.55) | HRH1SMN1; SMN2TDP1ALDH1A1HRH3 | |
| SCHEMBL31613157 | 0.76 | — | — | |
| SCHEMBL11787969 | 0.76 | — | — | |
| SCHEMBL15999400 | 0.76 | — | — | |
| SCHEMBL1140168 | 0.76 | — | — | |
| SCHEMBL533670 | 0.75 | SMN1; SMN2 (0.44) | HRH1SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL26555048 | 0.75 | SMN1; SMN2 (0.47) | HRH1SMN1; SMN2MAPTLIN28ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040204340-A1 | Polyprolyl inhibitors of cyclophilin | GUILFORD PHARMACEUTICALS, INC. | 2004-10-14 | — | — | US | disclosed |