Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6442557 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTL3MBTL1HTT | |
| SCHEMBL27492967 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MAPTL3MBTL1HTT | |
| SCHEMBL6363517 | 0.80 | GAA (0.46) | SMN1; SMN2ALDH1A1MAPTL3MBTL1NPC1 | |
| SCHEMBL6629620 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1MAPTCNR1CNR2 | |
| SCHEMBL6629811 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL6806280 | 0.77 | HRH1 (0.39) | SMN1; SMN2 | |
| SCHEMBL3579847 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL6200618 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL6806899 | 0.75 | MEN1 (0.36) | SMN1; SMN2ALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL6629342 | 0.75 | MEN1 (0.36) | SMN1; SMN2ALDH1A1HPGDPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770645-B2 | SEXUAL DISORDERS THERAPY; ANTIALLERGENS; RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2004-08-03 | — | — | US | disclosed |
| US-20030064990-A1 | Pharmaceutically active compounds | PFIZER INC. | 2003-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030064990-A1 | Pharmaceutically active compounds | PDE5A, PDE3A, PDE2A | SMN1; SMN2 2159/4885ALDH1A1 621/4885MAPT 4770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.