Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681297 | 1.00 | SLC6A2 (0.38) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 | |
| SCHEMBL680936 | 0.88 | SLC6A2 (0.40) | SLC6A2SLC6A4KCNH2CYP2D6SSTR4 | |
| SCHEMBL680723 | 0.88 | SLC6A2 (0.40) | SLC6A2SLC6A4KCNH2CYP2D6SSTR4 | |
| SCHEMBL681566 | 0.86 | MEN1 (0.40) | CYP2D6GAAHPGDSMN1; SMN2 | |
| SCHEMBL684480 | 0.85 | SLC6A4 (0.40) | SLC6A2SLC6A4KCNH2SLC6A3SSTR4 | |
| SCHEMBL684494 | 0.85 | SLC6A4 (0.40) | SLC6A2SLC6A4KCNH2SLC6A3SSTR4 | |
| SCHEMBL2738619 | 0.83 | CHEK1 (0.38) | — | |
| SCHEMBL2738616 | 0.83 | CHEK1 (0.38) | — | |
| SCHEMBL680141 | 0.83 | AKT3 (0.45) | CYP2D6GAAHPGDSMN1; SMN2 | |
| SCHEMBL680114 | 0.81 | BRD4 (0.42) | GAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |