Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817865 | 0.91 | HTT (0.44) | HTTAKR1C3AKR1C2KMT2AALDH1A1 | |
| SCHEMBL6817857 | 0.91 | HTT (0.44) | HTTAKR1C3AKR1C2KMT2AALDH1A1 | |
| SCHEMBL6820656 | 0.88 | MAPK1 (0.46) | KMT2AALDH1A1MAPTTDP1TP53 | |
| SCHEMBL6817328 | 0.82 | MAPT (0.44) | HTTAKR1C2KMT2AALDH1A1MAPT | |
| SCHEMBL6821228 | 0.81 | MAPK1 (0.46) | KMT2AALDH1A1MAPTTDP1MAPK1 | |
| SCHEMBL6905065 | 0.81 | AKR1C3 (0.49) | AKR1C3AKR1C2KMT2AALDH1A1MAPT | |
| SCHEMBL6820873 | 0.79 | MAPK1 (0.46) | KMT2AALDH1A1TDP1GAAMAPK1 | |
| SCHEMBL6817036 | 0.79 | MAPK1 (0.52) | KMT2AMAPTTDP1TP53MAPK1 | |
| SCHEMBL6817035 | 0.79 | MAPK1 (0.52) | KMT2AMAPTTDP1TP53MAPK1 | |
| SCHEMBL7646956 | 0.78 | AKR1C3 (0.46) | AKR1C3AKR1C2KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210320-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |
| US-6566554-B1 | Including amino benzothiophenones; useful for treatment of inflammatory diseases in which the production of cytokines is involved in the pathogenesis | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2003-05-20 | — | — | US | disclosed |