Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.73 |
| ▸ | RAB9A | P51151 | 12/20 | 0.73 |
| ▸ | POLB | P06746 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814478 | 0.96 | NPC1 (0.76) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6814492 | 0.84 | NPC1 (0.75) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6815353 | 0.83 | NPC1 (0.71) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6815339 | 0.82 | POLB (0.77) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6814497 | 0.81 | POLB (0.75) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6810773 | 0.80 | POLB (0.73) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6815374 | 0.80 | POLB (0.73) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL1756442 | 0.80 | POLB (0.73) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6810769 | 0.79 | POLB (0.81) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6814360 | 0.77 | NPC1 (0.76) | NPC1RAB9APOLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004012656-A2 | THIOPHENE AND FURAN DERIVATIVES AS PROSTAGLANDIN AGONISTS AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-02-12 | — | — | WO | disclosed |