SCHEMBL681510

SCHEMBL681510

CC(=O)Cc1cccs1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5198544 0.98 HPGD (0.55)
SCHEMBL7353467 0.82 HPGD (0.60)
SCHEMBL2333029 0.82
Methyl Alcohol SCHEMBL11407062 0.81 CYP2C19 (0.55)
SCHEMBL3757996 0.80
SCHEMBL621289 0.80
SCHEMBL4232556 0.79 POLB (0.50)
SCHEMBL11405212 0.79 CYP2C19 (0.53)
SCHEMBL5045391 0.79 HPGD (0.53)
Acetamide SCHEMBL11686256 0.79 MEN1 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 355 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107216309-A A kind of preparation technology of Duloxetine 武汉励合生物医药科技有限公司 2017-09-29 CN claimed
CN-1950513-B Method for producing optically active alcohols from alkane ketone by using dehydrogenase of azoarcus BASF AG 2012-09-05 CN claimed
EP-1969132-B1 ENZYMATIC REDUCTION FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS BASF SE (DE) 2011-03-02 EP claimed
US-7888080-B2 enzymically reducing the corresponding ketones to prepare alkanols; preparing (1S)-3-methylamino-1-(2-thienyl)propan-1-ol and (1S)-3-chloro-1-(2-thienyl)propan-1-ol from 3-methylamino-1-(2-thienyl)propanone and 3-chloro-1-(2-thienyl)propanone; dehydrogenase BASF SE (DE) 2011-02-15 US claimed
US-7785847-B2 Method for producing optically active alcohols from alkanones using a dehydrogenase of azoarcus BASF SE (DE) 2010-08-31 US claimed
EP-1745133-B1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE ALCOHOLS EMPLOYING A DEHYDROGENASE DERIVED FROM AZOARCUS BASF SE (DE) 2009-07-15 EP claimed
US-20080318288-A1 Enzymatic Reduction for Producing Optically Active Alcohols BASF AKTEINGESELLSCHAFT (DE) 2008-12-25 US claimed
CN-101321876-A Enzymatic reduction for producing optically active alcohols BASF AG (DE) 2008-12-10 CN claimed
EP-1969132-A1 ENZYMATIC REDUCTION FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS BASF SE (DE) 2008-09-17 EP claimed
US-20080206824-A1 Method For Producing Optically Active Alcohols From Alkanones Using a Dehydrogenase of Azoarcus BASF AKTIENGESELLSCHAFT (DE) 2008-08-28 US claimed
EP-1863918-A2 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS BY MEANS OF ENZYMATIC REDUCTION BASF AKTIENGESELLSCHAFT (DE) 2007-12-12 EP claimed
CN-101031543-A Process for preparing aromatic thiophenyl ketones CIBA SC HOLDING AG (CH) 2007-09-05 CN claimed
WO-2007074070-A1 ENZYMATIC REDUCTION FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS BASF SE (DE) 2007-07-05 WO claimed
CN-1950513-A Method for producing optically active alcohols from alkane ketone by using dehydrogenase of azoarcus BASF AG (DE) 2007-04-18 CN claimed
EP-1745133-A2 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS BASF AKTIENGESELLSCHAFT (DE) 2007-01-24 EP claimed
EP-1718653-A1 GLUCOCORTICOID RECEPTOR MODULATOR COMPOUNDS AND METHODS- UTILITY Ligand Pharmaceuticals Inc. (US) 2006-11-08 EP claimed
WO-2006094945-A2 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS BY MEANS OF ENZYMATIC REDUCTION BASF AKTIENGESELLSCHAFT (DE) 2006-09-14 WO claimed
WO-2005108590-A2 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS FROM ALKANONES USING A DEHYDROGENASE OF AZOARCUS BASF AKTIENGESELLSCHAFT (DE) 2005-11-17 WO claimed
WO-2005082909-A1 GLUCOCORTICOID RECEPTOR MODULATOR COMPOUNDS AND METHODS- UTILITY LIGAND PHARMACEUTICALS INCORPORATED (US) 2005-09-09 WO claimed
US-4000328-A COFFEE, THIOPHENE KETONES FIRMENICH & CIE (CH) 1976-12-28 US claimed