SCHEMBL6815264

SCHEMBL6815264

COc1cc(Br)c(S(=O)(=O)Nc2ccc(C(F)(F)F)c(O[C@@H]3CCNC3)c2)cc1OC

nearest known ligand 0.71

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 11/20 0.71
HTR6 P50406 1/20 0.42
HTR2A P28223 1/20 0.40
AXL P30530 1/20 0.39
P2RY4 P51582 2/20 0.39
SGK1 O00141 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
SHMT2 P34897 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6815276 1.00 UTS2R (0.71) UTS2RHTR6HTR2AAXLP2RY4
SCHEMBL5835351 0.87 UTS2R (0.70) UTS2RHTR6SGK1MEN1KMT2A
Hydrochloric Acid SCHEMBL6820115 0.86 UTS2R (0.53) UTS2RHTR6HTR2AAXL
Hydrochloric Acid SCHEMBL6820106 0.86 UTS2R (0.53) UTS2RHTR6HTR2AAXL
SCHEMBL5835169 0.83 UTS2R (1.00) UTS2R
SCHEMBL5835165 0.83 UTS2R (1.00) UTS2R
SCHEMBL8294765 0.83 UTS2R (1.00) UTS2R
SCHEMBL5835477 0.79 UTS2R (0.91) UTS2R
SCHEMBL5835482 0.79 UTS2R (0.91) UTS2R
SCHEMBL6135427 0.78 UTS2R (0.67) UTS2RAXLSGK1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043366-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed