Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.45 |
| ▸ | PDE2A | O00408 | 10/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681174 | 1.00 | EPHX2 (0.45) | EPHX2PDE2AKCNH2WNT3ACACNA1H | |
| SCHEMBL681017 | 0.92 | PDE2A (0.45) | EPHX2PDE2AKCNH2 | |
| SCHEMBL680772 | 0.92 | PDE2A (0.45) | EPHX2PDE2AKCNH2 | |
| SCHEMBL681181 | 0.89 | EPHX2 (0.43) | EPHX2PDE2AKCNH2 | |
| SCHEMBL681600 | 0.89 | PDE2A (0.44) | EPHX2PDE2ACACNA1H | |
| SCHEMBL681243 | 0.89 | PDE2A (0.44) | EPHX2PDE2ACACNA1H | |
| SCHEMBL680796 | 0.88 | PDE2A (0.43) | EPHX2PDE2ACACNA1H | |
| SCHEMBL679692 | 0.88 | PDE2A (0.43) | EPHX2PDE2ACACNA1H | |
| SCHEMBL681018 | 0.88 | PDE2A (0.43) | EPHX2PDE2ACACNA1H | |
| SCHEMBL681009 | 0.88 | PDE2A (0.43) | EPHX2PDE2ACACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |