Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | AKT2 | P31751 | 2/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | TLR4 | O00206 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | PTH1R | Q03431 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681471 | 0.89 | OPRL1 (0.44) | OPRL1AKT1AKT2AKT3CXCR3 | |
| SCHEMBL17803816 | 0.88 | OPRL1 (0.34) | OPRL1AKT1AKT2AKT3P2RX7 | |
| SCHEMBL681263 | 0.87 | KMT2A (0.35) | OPRL1AKT1AKT2AKT3P2RX7 | |
| SCHEMBL683314 | 0.87 | OPRL1 (0.46) | OPRL1AKT1AKT2AKT3CXCR3 | |
| SCHEMBL681781 | 0.85 | PDE2A (0.42) | IDH1CNR2 | |
| SCHEMBL8217301 | 0.84 | OPRL1 (0.46) | OPRL1AKT1AKT2AKT3TLR4 | |
| SCHEMBL20235996 | 0.83 | OPRL1 (0.50) | OPRL1CXCR3P2RX7 | |
| SCHEMBL18482278 | 0.83 | OPRL1 (0.50) | OPRL1CXCR3P2RX7 | |
| SCHEMBL681300 | 0.82 | AKT3 (0.47) | OPRL1AKT1AKT2AKT3P2RX7 | |
| SCHEMBL22622557 | 0.81 | OPRL1 (0.47) | OPRL1IDH1PTH1RCNR2KDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |