Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 4/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.39 |
| ▸ | AKT1 | P31749 | 3/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681305 | 1.00 | OPRL1 (0.41) | OPRL1CCR1MEN1KMT2AMITF | |
| SCHEMBL681145 | 0.93 | OPRL1 (0.43) | OPRL1CCR1MEN1KMT2AMITF | |
| SCHEMBL680942 | 0.90 | CCR1 (0.43) | OPRL1CCR1MEN1KMT2AMITF | |
| SCHEMBL679642 | 0.90 | CCR1 (0.43) | OPRL1CCR1MEN1KMT2AMITF | |
| SCHEMBL684155 | 0.89 | OPRL1 (0.43) | OPRL1CCR1MEN1KMT2AMITF | |
| SCHEMBL684409 | 0.89 | OPRL1 (0.43) | OPRL1CCR1MEN1KMT2AMITF | |
| SCHEMBL2738624 | 0.87 | OPRL1 (0.42) | OPRL1CCR1MEN1KMT2AMITF | |
| SCHEMBL681206 | 0.83 | OPRL1 (0.44) | OPRL1CCR1MEN1KMT2AMITF | |
| SCHEMBL681566 | 0.82 | MEN1 (0.40) | MEN1KMT2AMITFAKT2AKT3 | |
| SCHEMBL684412 | 0.82 | OPRL1 (0.46) | OPRL1MEN1KMT2AMITFAKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |