Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.41 |
| ▸ | AKT2 | P31751 | 2/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.41 |
| ▸ | ATF4 | P18848 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681179 | 0.90 | AKT1 (0.51) | AKT1AKT2AKT3 | |
| SCHEMBL679652 | 0.88 | AKT1 (0.43) | AKT1AKT2AKT3ATF4SLC6A3 | |
| SCHEMBL17803815 | 0.88 | AKT1 (0.36) | AKT1AKT2AKT3SLC6A3SLC6A4 | |
| SCHEMBL12188592 | 0.86 | AKT1 (0.44) | AKT1AKT2AKT3ATF4SLC6A3 | |
| SCHEMBL680134 | 0.85 | EPHX1 (0.38) | AKT1AKT2AKT3SLC6A3NPC1 | |
| SCHEMBL2739098 | 0.83 | AKT1 (0.42) | AKT1AKT2AKT3ATF4SLC6A3 | |
| SCHEMBL681191 | 0.83 | AKT1 (0.44) | AKT1AKT2AKT3LMNACYP1A2 | |
| SCHEMBL681539 | 0.83 | AKT1 (0.44) | AKT1AKT2AKT3LMNACYP1A2 | |
| SCHEMBL680165 | 0.82 | AKT1 (0.36) | AKT1AKT2AKT3SLC6A3CYP2D6 | |
| SCHEMBL680141 | 0.82 | AKT3 (0.45) | AKT1AKT2AKT3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |