Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | TOP2A | P11388 | 3/20 | 0.57 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL831159 | 0.85 | EGFR (0.53) | EGFRTOP2ATOP2BKMT2AALDH1A1 | |
| SCHEMBL27781219 | 0.84 | EGFR (0.51) | EGFRTOP2ATOP2BKMT2AALDH1A1 | |
| SCHEMBL22198990 | 0.82 | EGFR (0.50) | EGFRTOP2ATOP2BKMT2AALDH1A1 | |
| SCHEMBL682003 | 0.82 | EGFR (0.50) | EGFRTOP2ATOP2BKMT2AALDH1A1 | |
| SCHEMBL22237929 | 0.79 | KMT2A (0.53) | EGFRTOP2ATOP2BKMT2AALDH1A1 | |
| SCHEMBL4173966 | 0.78 | EGFR (0.38) | EGFRTOP2ATOP2BKMT2AALDH1A1 | |
| SCHEMBL10251289 | 0.78 | EGFR (0.38) | EGFRTOP2ATOP2BKMT2AALDH1A1 | |
| SCHEMBL4174833 | 0.78 | PDE3B (0.40) | EGFRTOP2ATOP2BKMT2AMAPT | |
| SCHEMBL2178320 | 0.78 | EGFR (0.53) | EGFRTOP2ATOP2BKMT2AALDH1A1 | |
| SCHEMBL12435442 | 0.77 | KMT2A (0.50) | EGFRTOP2ATOP2BKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3719010-B1 | AROMATIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN) | 2023-07-26 | — | — | EP | disclosed |
| EP-3719010-B1 | AROMATIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN) | 2023-07-26 | — | — | EP | disclosed |
| US-11332457-B2 | Aromatic compound, pharmaceutical composition and use thereof | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2022-05-17 | — | — | US | disclosed |
| US-11332457-B2 | Aromatic compound, pharmaceutical composition and use thereof | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2022-05-17 | — | — | US | disclosed |
| US-11261170-B2 | Aromatic compound, pharmaceutical composition and use thereof | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2022-03-01 | — | — | US | disclosed |
| CN-111148742-B | Aromatic compound and pharmaceutical composition and application thereof | 四川科伦博泰生物医药股份有限公司 | 2021-11-16 | — | — | CN | disclosed |
| EP-3719010-A1 | AROMATIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2020-10-07 | — | — | EP | disclosed |
| EP-3719010-A1 | AROMATIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2020-10-07 | — | — | EP | disclosed |
| US-20200277277-A1 | AROMATIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2020-09-03 | — | — | US | disclosed |
| US-20200277277-A1 | AROMATIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2020-09-03 | — | — | US | disclosed |
| US-9790228-B2 | Heterocyclic kinase inhibitors | INTELLIKINE LLC (US) | 2017-10-17 | — | — | US | disclosed |
| US-20160168157-A1 | HETEROCYCLIC KINASE INHIBITORS | INTELLIKINE LLC | 2016-06-16 | — | — | US | disclosed |
| US-20160168157-A1 | HETEROCYCLIC KINASE INHIBITORS | INTELLIKINE LLC | 2016-06-16 | — | — | US | disclosed |
| US-9296742-B2 | Heterocyclic kinase inhibitors | INTELLIKINE LLC (US) | 2016-03-29 | — | — | US | disclosed |
| US-9296742-B2 | Heterocyclic kinase inhibitors | INTELLIKINE LLC (US) | 2016-03-29 | — | — | US | disclosed |
| US-20140206685-A1 | HETEROCYCLIC KINASE INHIBITORS | INTELLIKINE LLC (US) | 2014-07-24 | — | — | US | disclosed |
| US-20140206685-A1 | HETEROCYCLIC KINASE INHIBITORS | INTELLIKINE LLC (US) | 2014-07-24 | — | — | US | disclosed |
| US-20110281866-A1 | HETEROCYCLIC KINASE INHIBITORS | INTELLIKINE, INC. (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110281866-A1 | HETEROCYCLIC KINASE INHIBITORS | INTELLIKINE, INC. (US) | 2011-11-17 | — | — | US | disclosed |
| WO-2010036380-A1 | HETEROCYCLIC KINASE INHIBITORS | INTELLIKINE, INC. (US) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168157-A1 | HETEROCYCLIC KINASE INHIBITORS | MAP3K13, MAP3K3, CDK3 | EGFR 526/4885TOP2A 1796/4885TOP2B 1766/4885 |
| US-20140206685-A1 | HETEROCYCLIC KINASE INHIBITORS | MAP3K13, MAP3K3, CDK3 | EGFR 526/4885TOP2A 1796/4885TOP2B 1766/4885 |
| US-11332457-B2 | Aromatic compound, pharmaceutical composition and use thereof | PPARD, PPARA, PPARG | EGFR 870/4885TOP2A 4714/4885TOP2B 4556/4885 |
| US-20200277277-A1 | AROMATIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF | PPARD, PPARA, PPARG | EGFR 870/4885TOP2A 4714/4885TOP2B 4556/4885 |
| US-11261170-B2 | Aromatic compound, pharmaceutical composition and use thereof | PPARD, PPARA, PPARG | EGFR 870/4885TOP2A 4714/4885TOP2B 4556/4885 |
| US-20110281866-A1 | HETEROCYCLIC KINASE INHIBITORS | MAP3K13, MAP3K3, CDK3 | EGFR 526/4885TOP2A 1796/4885TOP2B 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.