Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 4/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 8/20 | 0.36 |
| ▸ | IDH2 | P48735 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | BCL6 | P41182 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6082791 | 1.00 | IDH1 (0.37) | IDH1SOS1IDH2IDO1BCL6 | |
| SCHEMBL6082490 | 0.96 | MDM2 (0.35) | IDH1SOS1IDH2BCL6MDM2 | |
| SCHEMBL6081890 | 0.87 | SOS1 (0.39) | IDH1SOS1IDH2IDO1 | |
| SCHEMBL6082255 | 0.84 | IDH1 (0.36) | IDH1SOS1IDH2IDO1BCL6 | |
| SCHEMBL6082249 | 0.84 | IDH1 (0.36) | IDH1SOS1IDH2IDO1BCL6 | |
| SCHEMBL6082565 | 0.82 | KDM4E (0.34) | — | |
| SCHEMBL6082474 | 0.80 | MDM2 (0.35) | IDH1SOS1IDH2IDO1BCL6 | |
| SCHEMBL6082481 | 0.80 | MDM2 (0.35) | IDH1SOS1IDH2IDO1BCL6 | |
| SCHEMBL6818651 | 0.79 | BRD4 (0.34) | — | |
| SCHEMBL6814612 | 0.77 | BCHE (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |