Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 14/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 14/20 | 0.71 |
| ▸ | MAPK11 | Q15759 | 14/20 | 0.71 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816785 | 0.96 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11MT-CO2 | |
| SCHEMBL6817820 | 0.87 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11MT-CO2 | |
| SCHEMBL6097137 | 0.85 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6817148 | 0.84 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6093762 | 0.84 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL1904637 | 0.84 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL7067747 | 0.83 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11MT-CO2 | |
| SCHEMBL6093728 | 0.83 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL1906421 | 0.82 | MAPK14 (0.87) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6821214 | 0.82 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210320-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |
| US-6566554-B1 | Including amino benzothiophenones; useful for treatment of inflammatory diseases in which the production of cytokines is involved in the pathogenesis | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2003-05-20 | — | — | US | disclosed |
| EP-1210320-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001005746-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-01-25 | — | — | WO | disclosed |