SCHEMBL6821143

SCHEMBL6821143

CN1CCC(Oc2cc(NS(=O)(=O)c3ccc(Sc4ccc(F)cc4)cc3Cl)ccc2C(F)(F)F)C1

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.63
HTR2C P28335 1/20 0.39
HTR2B P41595 1/20 0.39
HTR6 P50406 1/20 0.39
PPARG P37231 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6821135 1.00 UTS2R (0.63) UTS2RHTR2CHTR2BHTR6PPARG
SCHEMBL6817631 0.94 UTS2R (0.63) UTS2RPPARG
SCHEMBL6817637 0.94 UTS2R (0.63) UTS2RPPARG
SCHEMBL6820953 0.94 UTS2R (0.63) UTS2RPPARG
SCHEMBL6820947 0.94 UTS2R (0.63) UTS2RPPARG
SCHEMBL6822447 0.94 UTS2R (0.65) UTS2R
SCHEMBL6822449 0.94 UTS2R (0.65) UTS2R
SCHEMBL6820854 0.92 UTS2R (0.63) UTS2RPPARG
SCHEMBL6820857 0.92 UTS2R (0.63) UTS2RPPARG
SCHEMBL6821152 0.92 UTS2R (0.59) UTS2RHTR6PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO claimed
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed