Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.75 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CCR2 | P41597 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6117699 | 0.89 | GRIK1 (0.64) | GRIK1GRIK2CCR2 | |
| SCHEMBL6118285 | 0.87 | GRIK1 (0.61) | GRIK1GRIK2CCR2TP53MAPT | |
| SCHEMBL6117558 | 0.86 | GRIK1 (0.60) | GRIK1GRIK2CCR2 | |
| SCHEMBL8642549 | 0.86 | GRIK2 (1.00) | GRIK1GRIK2ALDH1A1POLBMAPT | |
| SCHEMBL6117784 | 0.84 | GRIK1 (0.58) | GRIK1GRIK2CCR2 | |
| SCHEMBL8762627 | 0.83 | GRIK1 (0.57) | GRIK1GRIK2ALDH1A1CCR2 | |
| SCHEMBL14136817 | 0.83 | GRIK2 (0.80) | GRIK1GRIK2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27783800 | 0.81 | GRIK1 (0.71) | GRIK1GRIK2ALDH1A1POLBHPGD | |
| SCHEMBL8762536 | 0.81 | GRIK1 (0.57) | GRIK1GRIK2CCR2 | |
| SCHEMBL8762492 | 0.81 | GRIK1 (0.57) | GRIK1GRIK2CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004048331-A1 | N-ARYLALKYL-3-AMINOALKOXYINDOLES AND THEIR USE AS 5-HT LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-06-10 | — | — | WO | disclosed |