SCHEMBL6822571

SCHEMBL6822571

COc1ccc2oc(-c3ccccc3)cc2c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 3/20 0.72
ABCG2 Q9UNQ0 3/20 0.64
ABCB1 P08183 1/20 0.64
MAOB P27338 3/20 0.63
TNKS O95271 1/20 0.61
CYP19A1 P11511 1/20 0.61
NPC1 O15118 3/20 0.52
RAB9A P51151 3/20 0.52
GPR55 Q9Y2T6 1/20 0.52
KDM4E B2RXH2 2/20 0.51
ALDH1A1 P00352 2/20 0.51
TP53 P04637 2/20 0.51
CYP3A4 P08684 2/20 0.51
MAPT P10636 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
LMNA P02545 1/20 0.51
THRB P10828 1/20 0.51
HPGD P15428 1/20 0.51
NFKB1 P19838 1/20 0.51
NFKB2 Q00653 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29873198 0.90 APP (0.82) APPABCG2MAOBTNKSNPC1
SCHEMBL14833013 0.90 APP (0.82) APPABCG2MAOBTNKSNPC1
SCHEMBL6822627 0.88 NPC1 (0.66) APPABCG2ABCB1TNKSCYP19A1
SCHEMBL11844763 0.85 APP (0.75) APPMAOBNPC1RAB9AKDM4E
SCHEMBL15157318 0.84 APP (0.68) APPABCG2ABCB1MAOBNPC1
SCHEMBL10901627 0.84 APP (0.68) APPABCG2ABCB1MAOBNPC1
SCHEMBL735788 0.84 APP (0.73) APPMAOBNPC1RAB9AKDM4E
SCHEMBL729457 0.84 APP (0.73) APPMAOBNPC1RAB9AKDM4E
SCHEMBL10047396 0.84 APP (0.73) APPABCG2ABCB1MAOBNPC1
SCHEMBL4602054 0.82 MAPT (0.56) APPABCG2ABCB1MAOBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004089939-A1 CONDENSED FURAN DERIVATIVES AS ADENOSINE ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-10-21 WO disclosed
US-5773463-A DECALCIFICATION OF BRAIN DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 1998-06-30 US disclosed
EP-0711272-A1 INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1996-05-15 EP disclosed
EP-0710237-A1 QUINOLIZIDINES WITH CALCIUM CHANNEL ANTAGONISTIC ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1996-05-08 EP disclosed
WO-1995004028-A1 INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-02-09 WO disclosed
WO-1995003302-A1 QUINOLIZIDINES WITH CALCIUM CHANNEL ANTAGONISTIC ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1995-02-02 WO disclosed
EP-0625979-A1 AZABRICYCLIC COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-11-30 EP disclosed
WO-1993015073-A1 AZABRICYCLIC COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-08-05 WO disclosed